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Exp Neurol 160:289299

Accordingly, decreased DHFR expression, accumulation of BH 2 , decreased BH 4 /BH 2 ratio, and eNOS uncoupling were observed in vitro, in hyperglycemic endothelial cells [96, 111]

Upon generation from GSH, GSSG can be either recycled back to GSH by GSR or excreted into the plasma ( In the next step, an evaluation of enzymatic antioxidants in cells was performed (Figure 4)

The acidified environment adds positive charge to the peptide, and that shared charge creates electrostatic repulsion between molecules